オクヤマ　ミチヒロ   Michihiro Okuyama   奥山　倫弘    所属   川崎医科大学  医学部 臨床医学　心臓血管外科学    職種   講師
言語種別	英語
発表タイトル	Inducible Depletion of Calpain-2 Fibrogenic Mesenchymal Cells Attenuates Angiotensin II- induced Abdominal Aortic Aneurysm Formation in Hypercholesterolemic Mice
会議名	2020 ATVB Scientific Sessions (virtual format due to COVID-19, recorded previously)
学会区分	国際学会及び海外の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	Michihiro Okuyama, Weihua Jiang, Aida Javidan, Lihua Yang, Venkateswaran Subramanian
発表年月日	2020/05/01
国名	アメリカ合衆国
開催地 （都市, 国名）	Chicago, IL
開催期間	2020/05/04～2020/05/06
学会抄録	Arteriosclerosis, Thrombosis, and Vascular Biology 40(Suppl_1),AMP158 2020
概要	Fibrogenic mesenchymal cells in the aortic media and adventitia play a critical role in Angiotensin II(AngII)-induced extracellular matrix remodeling during abdominal aortic aneurysm (AAA) formation in mice. Recently, we demonstrated that either pharmacological or genetic inhibition of calpain-2, a non-lysosomal calcium dependent cysteine protease, prevented AngII-induced AAAs in mice. The purpose of this study was to determine the functional contribution of fibrogenic mesenchymal cells-derived calpain-2 to AngII-induced AAA formation in mice. Fibrogenic mesenchymal cells-derived calpain-2 play a critical role in the development of AngII-induced AAA formation in mice.