オクヤマ　ミチヒロ   Michihiro Okuyama   奥山　倫弘    所属   川崎医科大学  医学部 臨床医学　心臓血管外科学    職種   講師
言語種別	英語
発表タイトル	Pharmacological Inhibition of Hippo-YAP Signaling Attenuates Angiotensin II-induced Ascending Aoftic Aneurysms in Male LDL Receptor Deficient Mice
会議名	2019 ATVB Scientific Sessions
学会区分	国際学会及び海外の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	Michihiro Okuyama, Weihua Jiang, Lihua Yang, Aida Javidan, Devi Thiagarajan, Venkateswaran Subramanian
発表年月日	2019/05/16
国名	アメリカ合衆国
開催地 （都市, 国名）	Boston, MA
開催期間	2019/05/14～2019/05/16
国際共著	国際共著
学会抄録	Arteriosclerosis, Thrombosis, and Vascular Biology 39(Suppl_1),A652
概要	Hippo-YAP signaling pathway is well known to regulate cell proliferation and differentiation. Mammalian STE20-like protein kinase 1 (MST1), a core component of the Hippo pathway, promotes cell apoptosis and inhibits cell proliferation. Recent studies showed MST1 inhibition, or activation of its downstream YAP signaling suppress vascular smooth muscle cell apoptosis. However, the functional role of Hippo-YAP in the development of aortic aneurysms is still unknown. The purpose of this study is to examine the effect of Hippo-YAP signaling inhibition by XMU-MP-1 (inhibitor of MST1 and 2) on AngII-induced ascending and abdominal aortic aneurysm formation in mice. Hippo-YAP signaling inhibition by XMU-MP-1 attenuates AngII-induced ascending aortic dilation, but did not influence abdominal aortic aneurysm formation in male LDL receptor -/- mice.