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オクヤマ ミチヒロ
Michihiro Okuyama
奥山 倫弘 所属 川崎医科大学 医学部 臨床医学 心臓血管外科学 職種 講師 |
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| 言語種別 | 英語 |
| 発表タイトル | Exogenous Vasohibin-2 Exacerbates Angiotensinn II-induced Ascending Aortic Aneurysms |
| 会議名 | 2016 ATVB Scientific Sessions |
| 学会区分 | 国際学会及び海外の学会 |
| 発表形式 | ポスター掲示 |
| 講演区分 | 一般 |
| 発表者・共同発表者 | Michihiro Okuyama, Haruhito A Uchida, Ryoko Umebayashi, Yuki Kakio, Katsuyuki Tanabe, Yasufumi Sato, Jun Wada |
| 発表年月日 | 2016/05/06 |
| 国名 | アメリカ合衆国 |
| 開催地 （都市, 国名） |
Nashville, TN |
| 開催期間 | 2017/05/05～2017/05/07 |
| 学会抄録 | Arteriosclerosis, Thrombosis, and Vascular Biology 36(suppl_1),A305 |
| 概要 | hronic angiotensin II (AngII) infusion promotes both ascending (TAAs) and abdominal aortic aneurysms (AAAs) in mice. Previous studies demonstrated that vascular endothelial growth factor (VEGF) enhanced AngII-induced AAA formation, and VEGF significantly increased AngII-induced AAA diameter in hypercholesterolemic mice. Vasohibin-1 (VASH-1) is induced by VEGF and inhibits angiogenesis at the termination zone under various pathologic conditions such as those of tumors, arterial intimal thickening and retinal neovasucularization. In contrast, a VASH-1 homolog, Vasohibin-2 (VASH-2), promotes angiogenesis at the sprouting front. Therefore, we hypothesized that exogenous VASH-2 influences AngII-induced TAAs in normocholesterolemic mice. The purpose of this study was to examine whether VASH-2 influenced AngII-induced TAAs.
Exogenous VASH-2 exacerbated AngII-induced ascending aortic aneurysms in male C57BL/6 mice. |