オクヤマ　ミチヒロ   Michihiro Okuyama   奥山　倫弘    所属   川崎医科大学  医学部 臨床医学　心臓血管外科学    職種   講師
言語種別	英語
発表タイトル	Vasohibin-2 exacerbates development of angiotensin II-induced thoracic aortic aneurysms independent of VEGF
会議名	ESC Congress 2017
学会区分	国際学会及び海外の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	Michihiro Okuyama, Haruhito A Uchida, Ryoko Umebayashi, Yuki Kakio, Hidemi Takeuchi, Katsuyuki Tanabe, Yasufumi Sato, Jun Wada
発表年月日	2017/08/29
国名	スペイン
開催地 （都市, 国名）	Barcelona
開催期間	2017/08/26～2017/08/30
学会抄録	European Heart Journal 38(suppl_1),ehx493, P5398 2017
概要	Chronic angiotensin II (AngII) infusion promotes both thoracic (TAAs) and abdominal aortic aneurysms (AAAs) in mice. Previous studies showed that vascular endothelial growth factor (VEGF) enhanced AngII-induced AAA formation, and VEGF significantly increased Angll-induced AAA diameter in hypercholesterolemic mice. Meanwhile, vasohibin-1 (VASH1) is induced by VEGF and inhibits angiogenesis under various pathologic conditions. In contrast, a VASH1 homolog, vasohibin-2 (VASH2) promotes angiogenesis at the sprouting front of neovascularization. Therefore, we hypothesized that exogenous VASH2 influences AngII-induced TAAs in normocholesterolemic mice. Exogenous VASH2 administration expands AngII-induced TAAs in vivo. VASH2 may accelerate MMP-2 activation. VASH2-induced cell apoptosis may influence AngII-induced TAA formation independent of VEGF.