ヤマウチ　アキラ   Akira Yamauchi   山内　明    所属   川崎医科大学  医学部 基礎医学　生化学    職種   教授
言語種別	日本語
発表タイトル	細胞動態アッセイデバイスTAXIScanで見出された化合物は腫瘍増大と転移の両方を抑える
会議名	第81回日本癌学会学術総会
主催者	日本癌学会
学会区分	全国規模の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	山内明、山村真弘、片瀬直樹、友信奈保子、木下理恵、阪口政清、岡本秀一郎
発表年月日	2022/09/29
開催地 （都市, 国名）	横浜、日本
概要	Pancreatic cancer is one of the worst prognostic cancers and is highly metastatic and progressive. To conquer this malignant tumor, we utilized the cell dynamics assay device established previously to perform screening to find novel compounds regulating the migration of human pancreatic BxPC-3 cells. One of the hit compounds, Compound 14-100, showed the anti-tumor effect in vivo such as inhibiting metastasis based on the observation of fluorescent labeled tumor implants through the skin. Unexpectedly, the compound showed the inhibitory effect on the tumor proliferation despite with less cytotoxicity. Single cell RNA-seq revealed the change of gene expressions with regard to metastasis, angiogenesis, inflammation, and epithelial mesenchymal transition. These data suggest that compound 14-100 is effective to treat pancreatic cancer, which embodies "Cell-based Drug Discovery" especially focusing on cell dynamics.