Takuya Moriya    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Pathology,    Position   Professor
Article types	症例報告
Language	English
Peer review	Peer reviewed
Title	[A Case Report of Surgery and Chemotherapy for a Patient with Rapidly Progressing Breast Cancer during Pregnancy].
Journal	Formal name：Gan to kagaku ryoho. Cancer & chemotherapy Abbreviation：Gan To Kagaku Ryoho ISSN code：03850684/03850684
Domestic / Foregin	Foregin
Volume, Issue, Page	45(5),pp.847-850
Author and coauthor	Hazama Yukiko, Nakai Yuichiro, Sugawara Shiori, Nomura Tsunehisa, Matsumoto Keiko, Matsumoto Ryou, Sugihara Mika, Ishida Tsuyoshi, Murata Susumu, Murata Takuya, Nakamura Takafumi, Moriya Takuya, Kurebayashi Junichi, Shimoya Koichiro
Publication date	2018/05
Summary	A 33-year-old woman became aware of a right breast mass at her 28th week of pregnancy. From the biopsy results, we diagnosed her with right breast cancer. At her 33rd week of pregnancy, she underwent modified radical mastectomy (pT2N3aM0, Stage III C, ER-negative, PR-negative, HER2-positive), and she elected to receive adjuvant therapy after the surgery during her pregnancy. She received the first course of EC (epirubicin plus cyclophosphamide) therapy on the 13th postoperative day (35 weeks of gestation) and gave a natural, vaginal delivery at 36 weeks and 5 days of gestation. On the 4th day after birth, the patient noticed a contralateral left breast mass and was diagnosed with left breast cancer, after core needle biopsy. She received 4 courses of EC therapy and is currently undergoing PTX plus HER (paclitaxel plus trastuzumab) therapy. Regarding chemotherapy during pregnancy, we recommend that there is no need to perform artificial preterm birth, because chemotherapy has little influence on children after their second-trimester. After the second-trimester, chemotherapy can be safely performed.
PMID	30026449