Katsuhiko Ishihara    Department   Kawasaki University of Medical Welfare  ,    Position   Professor with Special Assignment
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease.
Journal	Formal name：Front. Behav. Neurosci
Volume, Issue, Page	8,pp.133
Author and coauthor	Olga Lopatina, Toru Yoshihara, Tomoko Nishimura, Jing Zhong, Shirin Akther, Azam AKM Fakhrul, Mingkun Liang, Chiharu Higashida, Kohei Sumi, Kazumi Furuhara, Yuki Inahata, Jianjun Huang, Keita Koizumi, Shigeru Yokoyama, Takahiro Tsuji, Yu Petugina, Andrei Sumarukov, Alla B. Salmina, Koji Hashida, Yasuko Kitao, Osamu Hori, Masahide Asano, Yoji Kitamura, Takashi Kozaka, Kazuhiro Shiba, Fangfang Zhong, Min-Jue Xie, Makoto Sato, Katsuhiko Ishihara, Haruhiro Higashida.
Publication date	2014/04
Summary	CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in Parkinson's disease (PD), little is known about the function of CD157 in the nervous system and contribution to PD progression. Here, we show that no apparent motor dysfunction was observed in young knockout (CD157 (-/-)) male mice under less aging-related effects on behaviors. CD157 (-/-) mice exhibited anxiety-related and depression-like behaviors compared with wild-type mice. These behaviors were rescued through treatment with anti-psychiatric drugs and oxytocin. CD157 was weakly expressed in the amygdala and c-Fos immunoreactivity in the amygdala was less evident in CD157 (-/-) mice than in wild-type mice. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in PD.
DOI	10.3389/fnbeh.2014.00133