ニシマツ シンイチロウ
Shinichiro Nishimatsu
西松 伸一郎 所属 川崎医科大学 医学部 一般教養 自然科学 職種 教授 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis. |
掲載誌名 | 正式名:Proceedings of the National Academy of Sciences of the United States of America 略 称:Proc Natl Acad Sci U S A ISSNコード:00278424/10916490 |
巻・号・頁 | 88(15),pp.6511-6514 |
著者・共著者 | Asashima Makoto, Nakano Hiroshi, Uchiyama Hideho, Sugino Hiromu, Nakamura Takanori, Eto Yuzuru, Ejima Daisuke, Nishimatsu Shin-ichiro, Ueno Naoto, Kinoshita Kei |
発行年月 | 1991/08 |
概要 | Activin A, a member of the transforming growth factor beta superfamily, has recently been found to have potent mesoderm-inducing activity on isolated early Xenopus animal-cap cells. We measured the activin activity of the Xenopus egg extract by using an erythroid-differentiating test with Friend leukemia cells. The results showed that an activin homologue is, indeed, contained in unfertilized eggs and blastulae of Xenopus laevis in a considerable amount. This activity was eluted at the same retention time as human activin A when fractionated by reversed-phase HPLC. Furthermore, the fraction containing erythroid-differentiating factor activity had mesoderm-inducing activity on Xenopus animal-cap cells. The mesoderm-inducing activity of this fraction was suppressed when coincubated with follistatin, an activin-binding protein. These results suggest that an endogenous activin may be a natural mesoderm-inducing factor acting in Xenopus embryogenesis. |
DOI | 10.1073/pnas.88.15.6511 |
文献番号 | 1862079 |