ニシマツ　シンイチロウ   Shinichiro Nishimatsu   西松　伸一郎    所属   川崎医科大学  医学部 一般教養　自然科学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis.
掲載誌名	正式名：Proceedings of the National Academy of Sciences of the United States of America 略　 称：Proc Natl Acad Sci U S A ISSNコード：00278424/10916490
巻・号・頁	88(15),pp.6511-6514
著者・共著者	Asashima Makoto, Nakano Hiroshi, Uchiyama Hideho, Sugino Hiromu, Nakamura Takanori, Eto Yuzuru, Ejima Daisuke, Nishimatsu Shin-ichiro, Ueno Naoto, Kinoshita Kei
発行年月	1991/08
概要	Activin A, a member of the transforming growth factor beta superfamily, has recently been found to have potent mesoderm-inducing activity on isolated early Xenopus animal-cap cells. We measured the activin activity of the Xenopus egg extract by using an erythroid-differentiating test with Friend leukemia cells. The results showed that an activin homologue is, indeed, contained in unfertilized eggs and blastulae of Xenopus laevis in a considerable amount. This activity was eluted at the same retention time as human activin A when fractionated by reversed-phase HPLC. Furthermore, the fraction containing erythroid-differentiating factor activity had mesoderm-inducing activity on Xenopus animal-cap cells. The mesoderm-inducing activity of this fraction was suppressed when coincubated with follistatin, an activin-binding protein. These results suggest that an endogenous activin may be a natural mesoderm-inducing factor acting in Xenopus embryogenesis.
DOI	10.1073/pnas.88.15.6511
文献番号	1862079