ニシマツ　シンイチロウ   Shinichiro Nishimatsu   西松　伸一郎    所属   川崎医科大学  医学部 一般教養　自然科学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Expression of thymosin beta4 gene during Xenopus laevis embryogenesis.
掲載誌名	正式名：Biochemical and biophysical research communications 略　 称：Biochem Biophys Res Commun ISSNコード：0006291X/10902104
巻・号・頁	184(15),pp.93-99
著者・共著者	Yamamoto Masaya, Shoda Akihito, Minamino Naoto, Matsuo Hisayuki, Nishimatsu Shin-ichiro, Ueno Naoto, Murakami Kazuo
発行年月	1992/04
概要	In order to investigate the molecular events which take place during gastrulation, extracts from developing Xenopus embryos were analyzed for temporal peptide distribution by high performance liquid chromatography. One peptide peak which became increasingly dominant after gastrulation was purified and partially characterized. The amino acid sequence of enzymic digests showed the peptide is extremely similar to mammalian thymosin beta4. The peptide was capable of binding actin monomers like mammalian counterparts. Cloning of the Xenopus thymosin beta4 cDNA showed that only three amino acid substitutions occurred between amphibian and bovine. Northern blot analysis revealed the mRNA is maternally present at a low level and the transcript becomes abundant after gastrulation, supporting the distribution of the peptide.
DOI	10.1016/0006-291X(92)91162-J
文献番号	1567461