ニシマツ　シンイチロウ   Shinichiro Nishimatsu   西松　伸一郎    所属   川崎医科大学  医学部 一般教養　自然科学    職種   教授
論文種別	総説
言語種別
査読の有無	査読なし
表題	骨形成タンパク質(BMP)の遺伝子とその生物学的機能
掲載誌名	正式名：日本硬組織研究技術学会雑誌 ISSNコード：13417649
巻・号・頁	5(2),110-118頁
著者・共著者	上野直人, 西松伸一郎, 正田昭士, 鈴木厚, 竹林公子, 山岸敏之, 村上和雄
担当区分	2nd著者
発行年月	1996/07
概要	Characterization of Xencpus BMP genes. We have previously demonstrated that activin, a member of the TGF-b family, has a potent mesoderm-inducing activity in Xenopus embryos. Activin can effrciently induce mesoderln formation that is associated with Eφ-activin gene activation when applied to the culture of isolated presumptive ectoderm (animal cap). In the course of screening for activin-related genes from Xenopus, we isolated a gene which predicts a protein which is extremely similar to human BMP-2 (bone morphogenetic protein-2) which had previously isolated for its ability to induce ectopic bone formation. Subsequently, we have cloned cDNAs for Xenopus homologue of BMP-2, -4 and -7 (Fig. 1A, 1B). Deduced protein structure of Xenopus BMP-2, -4 and 7 suggested that they all are synthesized as large precursor proteins of 398, 401, 428 amino acids, and processed to mature proteins of 114, 114, and 428 amino acids. Northern blot analysis revealed that these BMP genes are maternally encoded and differentially regulated after fertilization (Fig. 2).
文献番号	1997041160