ニシマツ シンイチロウ
Shinichiro Nishimatsu
西松 伸一郎 所属 川崎医科大学 医学部 一般教養 自然科学 職種 教授 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Expression of bone morphogenetic protein-5 gene during chick heart development: possible roles in valvuloseptal endocardial cushion formation. |
掲載誌名 | 正式名:The Anatomical record 略 称:Anat Rec ISSNコード:0003276X/10970185 |
巻・号・頁 | 264(4),pp.313-316 |
著者・共著者 | Yamagishi Toshiyuki, Nakajima Yuji, Nishimatsu Shin-ichiro, Nohno Tsutomu, Ando Katsumi, Nakamura Hiroaki |
発行年月 | 2001/12 |
概要 | The bone morphogenetic protein (BMP) family, comprising multifunctional peptide growth factors, regulates many developmental processes in a variety of tissues. We examined the spatiotemporal expression of BMP5 by in situ hybridization in chick embryonic hearts from stages 5 to 33. The BMP5 gene was first expressed in the endoderm underlying the precardiac mesoderm at stages 5 to 8. Thereafter, BMP5 expression was restricted to the myocardium of the atrioventricular (AV) canal and outflow tract (OT) regions, where the valvuloseptal endocardial cushion tissue is induced. These results suggest that BMP5 may play important roles not only in myocardial differentiation, but also in the formation and maintenance of endocardial cushion tissue. |
DOI | 10.1002/ar.10013 |
文献番号 | 11745086 |