ニシマツ　シンイチロウ   Shinichiro Nishimatsu   西松　伸一郎    所属   川崎医科大学  医学部 一般教養　自然科学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Differential expression of the frizzled family involved in Wnt signaling during chick limb development.
掲載誌名	正式名：Cellular and molecular biology (Noisy-le-Grand, France) 略　 称：Cell Mol Biol (Noisy-le-grand) ISSNコード：01455680/1165158X
巻・号・頁	45(5),pp.653-659
著者・共著者	Nohno Tsutomu, Kawakami Yasuhiko, Wada Naoyuki, Komaguchi Chikako, Nishimatsu Shin-ichiro
担当区分	最終著者
発行年月	1999/07
概要	Members of the frizzled (Fz) family are involved in Wnt signaling during embryogenesis in the vertebrate. We identified chicken cognates of Fz-2, Fz-3, Fz-4, Fz-6 and Fz-8, and examined spatial and temporal expression patterns in the chick embryos by whole-mount in situ hybridization. Fz-4 is intensely expressed in the apical ectodermal ridge and distal mesenchyme of the limb bud at stages 20 to 27. The transcripts are confined to the posterior-distal end of the digit-forming region at stages 25 to 27. Fz-2 is weakly expressed in the proximal limb mesenchyme at stages 25 to 27, while Fz-3 and Fz-6 expressions are uniform in the limb bud at these stages. Fz-2 is also expressed in the dermatomyotome. No expression signal for Fz-8 is detectable in the embryo at stages 20 to 27. The differential expression patterns of the Fz family, together with spatially restricted expression of the Wnt family members in the developing limb, suggest distinct but overlapping functions to transduce Wnt signal implicated in cellular interaction during embryogenesis.
文献番号	10512196