Hironobu Katsuyama
Department Kawasaki Medical School Kawasaki Medical School, Department of Public Health, Position Professor |
|
Article types | 原著 |
Language | English |
Peer review | Peer reviewed |
Title | Changes in gene expression level for defense system enzymes against oxidative stress and glutathione level in rat administered paraquat. |
Journal | Formal name:International journal of molecular medicine Abbreviation:Int J Mol Med ISSN code:11073756/1791244X |
Volume, Issue, Page | 15(4),pp.689-693 |
Author and coauthor | Tomita Masafumi, Katsuyama Hironobu, Okuyama Toshiko, Hidaka Kazuo, Minatogawa Yohsuke |
Authorship | 2nd author |
Publication date | 2005/04 |
Summary | We examined the effect of PQ on the relative levels of gene expression of antioxidant enzymes and glutathione (GSH) status in lungs of rats exposed to 20 mg/kg PQ. At 16 h after PQ intake, the mRNA expression level of glutathione reductase (GR) showed the greatest increase, and those of catalase (CAT) and manganese-superoxide dismutase (MnSOD) showed more modest increases. In contrast, PQ had little or no effect on the levels of mRNAs for copper/zinc-superoxide dismutase (CuZnSOD) and glutathione peroxidase (GPX). |
Document No. | 15754033 |