Hironobu Katsuyama
   Department     ,
Article types 原著
Language English
Peer review Peer reviewed
Title Changes in gene expression level for defense system enzymes against oxidative stress and glutathione level in rat administered paraquat.
Journal Formal name:International journal of molecular medicine
Abbreviation:Int J Mol Med
ISSN code:11073756/1791244X
Volume, Issue, Page 15(4),689-693頁
Author and coauthor Tomita Masafumi, Katsuyama Hironobu, Okuyama Toshiko, Hidaka Kazuo, Minatogawa Yohsuke
Publication date 2005/04
Summary We examined the effect of PQ on the relative levels of gene expression of antioxidant enzymes and glutathione (GSH) status in lungs of rats exposed to 20 mg/kg PQ. At 16 h after PQ intake, the mRNA expression level of glutathione reductase (GR) showed the greatest increase, and those of catalase (CAT) and manganese-superoxide dismutase (MnSOD) showed more modest increases. In contrast, PQ had little or no effect on the levels of mRNAs for copper/zinc-superoxide dismutase (CuZnSOD) and glutathione peroxidase (GPX).
Document No. 15754033