カツヤマ ヒロノブ   Hironobu Katsuyama
  勝山 博信
   所属   川崎医科大学  医学部 臨床医学 公衆衛生学
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Changes in gene expression level for defense system enzymes against oxidative stress and glutathione level in rat administered paraquat.
掲載誌名 正式名:International journal of molecular medicine
略  称:Int J Mol Med
ISSNコード:11073756/1791244X
巻・号・頁 15(4),689-693頁
著者・共著者 Tomita Masafumi, Katsuyama Hironobu, Okuyama Toshiko, Hidaka Kazuo, Minatogawa Yohsuke
発行年月 2005/04
概要 We examined the effect of PQ on the relative levels of gene expression of antioxidant enzymes and glutathione (GSH) status in lungs of rats exposed to 20 mg/kg PQ. At 16 h after PQ intake, the mRNA expression level of glutathione reductase (GR) showed the greatest increase, and those of catalase (CAT) and manganese-superoxide dismutase (MnSOD) showed more modest increases. In contrast, PQ had little or no effect on the levels of mRNAs for copper/zinc-superoxide dismutase (CuZnSOD) and glutathione peroxidase (GPX).
文献番号 15754033