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Tomoharu Tokutomi
Department Kawasaki Medical School Kawasaki Medical School, Department of Pediatrics, Position Professor with Special Assignment |
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| Article types | 原著 |
| Language | English |
| Peer review | Peer reviewed |
| Title | Intravenous immunoglobulin therapy induces neutrophil apoptosis in Kawasaki disease. |
| Journal | Formal name：Clinical immunology (Orlando, Fla.) ISSN code：1521-6616 |
| Domestic / Foregin | Foregin |
| Publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| Volume, Issue, Page | 103(2),pp.161-8 |
| Author and coauthor | Hiroshi Tsujimoto,Seiichiro Takeshita,Keigo Nakatani,Youichi Kawamura,Tomoharu Tokutomi,Isao Sekine |
| Publication date | 2002/05 |
| Summary | To investigate the effect of high-dose intravenous immunoglobulin (IVIg) on neutrophil apoptosis in Kawasaki disease (KD), we studied the in vitro spontaneous and IVIg-induced apoptosis of neutrophils by analyzing a proportion of annexin V-positive cells and cells with fragmented DNA. The mean number of peripheral neutrophils in the post-IVIg phase decreased significantly (P < 0.01) compared with that in the pre-IVIg phase. The mean proportion of spontaneous apoptotic neutrophils in the post-IVIg phase was significantly higher (P < 0.01) than that in the pre-IVIg phase, and there was a significantly positive correlation (P < 0.01) with the reduction ratio of the circulating neutrophil counts from the pre-IVIg through the post-IVIg phases. IVIg induced a dose-dependent increase in the proportion of apoptotic neutrophils in the pre-IVIg phase. As a result, the present study demonstrated a novel action in which high-dose IVIg therapy decreased the number of circulating neutrophils by accelerating their apoptosis in KD. (C) 2002 Elsevier Science (USA). |
| DOI | 10.1006/clim.2002.5209 |
| PMID | 12027421 |