Tomoharu Tokutomi
   Department   Kawasaki Medical School  Kawasaki Medical School, Department of Pediatrics,
   Position   Professor with Special Assignment
Article types 原著
Language English
Peer review Peer reviewed
Title Population-based biobank participants' preferences for receiving genetic test results.
Journal Formal name：Journal of human genetics
ISSN code：1434-5161/1435-232X
Domestic / ForeginForegin
Publisher NATURE PUBLISHING GROUP
Volume, Issue, Page 62(12),pp.1037-1048
Author and coauthor Kayono Yamamoto,Tsuyoshi Hachiya,Akimune Fukushima,Naoki Nakaya,Akira Okayama,Kozo Tanno,Fumie Aizawa,Tomoharu Tokutomi,Atsushi Hozawa,Atsushi Shimizu
Publication date 2017/12
Summary There are ongoing debates on issues relating to returning individual research results (IRRs) and incidental findings (IFs) generated by genetic research in population-based biobanks. To understand how to appropriately return genetic results from biobank studies, we surveyed preferences for returning IRRs and IFs among participants of the Tohoku Medical Megabank Project (TMM). We mailed a questionnaire to individuals enrolled in the TMM cohort study (Group 1; n=1031) and a group of Tohoku region residents (Group 2; n= 2314). The respondents were required to be over 20 years of age. Nearly 90% of Group 1 participants and over 80% of Group 2 participants expressed a preference for receiving their genetic test results. Furthermore, over 60% of both groups preferred to receive their genetic results 'from a genetic specialist.' A logistic regression analysis revealed that engaging in 'health-conscious behaviors' (such as regular physical activity, having a healthy diet, intentionally reducing alcohol intake and/ or smoking and so on) was significant, positively associated with preferring to receive their genetic test results (odds ratio=2.397 (Group 1) and 1.897 (Group 2)). Our findings provided useful information and predictors regarding the return of IRRs and IFs in a population-based biobank.
DOI 10.1038/jhg.2017.81
PMID 28794501