Hiroshi Ushirogawa    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Microbiology,    Position   Instructor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin.
Journal	Formal name：Virology Journal Abbreviation：Virol J
Volume, Issue, Page	8,pp.50 (1-8)
Author and coauthor	Tokunaga Hirotoshi, Ushirogawa Hiroshi, Ohuchi Masanobu
Authorship	2nd author
Publication date	2011/02
Summary	Background Mannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses. Since a majority of humans have no neutralizing antibody against the pandemic (H1N1) 2009 influenza (pandemic 2009) virus, innate immunity may be crucial and MBL susceptibility may therefore influence viral pathogenesis. Results We examined MBL susceptibility of influenza A viruses and observed that the pandemic 2009 virus was resistant to MBL, whereas all seasonal influenza A viruses tested were susceptible. The mortality of mice infected with a seasonal H1N1 influenza virus was evidently enhanced on transient blockage of MBL activity by simultaneous inoculation of mannan, whereas mannan inoculation had no effect on mice infected with a pandemic 2009 virus. This indicates that MBL protects mice against infection with the seasonal virus but not against that with the pandemic 2009 virus. Conclusion These results indicate that the pandemic 2009 virus is not susceptible to MBL, an important component of innate immunity.
DOI	10.1186/1743-422X-8-50
Document No.	PMID: 21294904