テラワキ セイゴウ
Seigo Terawaki
寺脇 正剛 所属 川崎医科大学 医学部 基礎医学 分子遺伝医学 職種 特任講師 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages. |
掲載誌名 | 正式名:Royal Society open science 略 称:R Soc Open Sci ISSNコード:20545703/20545703 |
掲載区分 | 国外 |
巻・号・頁 | 8(7),pp.202333 |
著者・共著者 | Valečka Jan, Camosseto Voahirana, McEwan David G, Terawaki Seigo, Liu Zhuangzhuang, Strock Eva, Almeida Catarina R, Su Bing, Dikic Ivan, Liang Yinming, Gatti Evelina, Pierre Philippe |
発行年月 | 2021/07 |
概要 | We report here that RUFY4, a newly characterized member of the 'RUN and FYVE domain-containing' family of proteins previously associated with autophagy enhancement, is highly expressed in alveolar macrophages (AM). We show that RUFY4 interacts with mitochondria upon stimulation by microbial-associated molecular patterns of AM and dendritic cells. RUFY4 interaction with mitochondria and other organelles is dependent on a previously uncharacterized OmpH domain located immediately upstream of its C-terminal FYVE domain. Further, we demonstrate that rufy4 messenger RNA can be translated from an alternative translation initiation codon, giving rise to a N-terminally truncated form of the molecule lacking most of its RUN domain and with enhanced potential for its interaction with mitochondria. Our observations point towards a role of RUFY4 in selective mitochondria clearance in activated phagocytes. |
DOI | 10.1098/rsos.202333 |
PMID | 34295519 |