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Seigo Terawaki
Department Kawasaki Medical School Kawasaki Medical School, Department of Molecular and Genetic Medicine, Position Assistant Professor with Special Assignment |
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| Article types | 原著 |
| Language | English |
| Peer review | Peer reviewed |
| Title | Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice. |
| Journal | Formal name：Inflammation research : official journal of the European Histamine Research Society ... [et al.] Abbreviation：Inflamm Res ISSN code：1420908X/10233830 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 70(5),pp.539-541 |
| Author and coauthor | Iwasaki Naruhito, Terawaki Seigo, Shimizu Kouhei, Oikawa Daisuke, Sakamoto Hirokazu, Sunami Kishiko, Tokunaga Fuminori |
| Publication date | 2021/05 |
| Summary | OBJECTIVE:Histamine derived from mast cells and basophils plays important roles in inducing allergic symptoms. Although T cells also produce histamine, the involvement of the histamine produced from T cells has remained enigmatic. We sought to reveal the roles of T helper 2 (Th2) cell-derived histamine in nasal allergic disorders.METHODS:The histamine production from Th2 cells was measured by EIA. The mRNA expression of histidine decarboxylase (HDC) was measured by real-time PCR. To investigate the roles of Th2 cell-derived histamine in vivo, we analyzed an antigen-specific Th2 cell transfer mouse model.RESULTS:Th2 cells produced histamine by T cell receptor stimulation, and these properties were specific for Th2 cells, but not Th1 cells and naïve CD4 T cells. The histamine produced from Th2 cells was involved in the infiltrations of Th2 cells in response to antigen exposure.CONCLUSION:These results suggest that Th2 cell-derived histamine play important roles in nasal allergic disorders. |
| DOI | 10.1007/s00011-021-01458-x |
| PMID | 33811487 |