テラワキ セイゴウ   Seigo Terawaki
  寺脇 正剛
   所属   川崎医科大学  医学部 基礎医学 分子遺伝医学
   職種   特任講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice.
掲載誌名 正式名:Inflammation research : official journal of the European Histamine Research Society ... [et al.]
略  称:Inflamm Res
ISSNコード:1420908X/10233830
掲載区分国外
巻・号・頁 70(5),539-541頁
著者・共著者 Iwasaki Naruhito, Terawaki Seigo, Shimizu Kouhei, Oikawa Daisuke, Sakamoto Hirokazu, Sunami Kishiko, Tokunaga Fuminori
発行年月 2021/05
概要 OBJECTIVE:Histamine derived from mast cells and basophils plays important roles in inducing allergic symptoms. Although T cells also produce histamine, the involvement of the histamine produced from T cells has remained enigmatic. We sought to reveal the roles of T helper 2 (Th2) cell-derived histamine in nasal allergic disorders.METHODS:The histamine production from Th2 cells was measured by EIA. The mRNA expression of histidine decarboxylase (HDC) was measured by real-time PCR. To investigate the roles of Th2 cell-derived histamine in vivo, we analyzed an antigen-specific Th2 cell transfer mouse model.RESULTS:Th2 cells produced histamine by T cell receptor stimulation, and these properties were specific for Th2 cells, but not Th1 cells and naïve CD4 T cells. The histamine produced from Th2 cells was involved in the infiltrations of Th2 cells in response to antigen exposure.CONCLUSION:These results suggest that Th2 cell-derived histamine play important roles in nasal allergic disorders.
DOI 10.1007/s00011-021-01458-x
PMID 33811487