テラワキ　セイゴウ   Seigo Terawaki   寺脇　正剛    所属   川崎医科大学  医学部 基礎医学　分子遺伝医学    職種   特任講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells.
掲載誌名	正式名：Immunity 略　 称：Immunity ISSNコード：10747613/10747613
掲載区分	国外
巻・号・頁	17(1),pp.31-40
著者・共著者	Fukuyama Satoshi, Hiroi Takachika, Yokota Yoshifumi, Rennert Paul D, Yanagita Manabu, Kinoshita Naotoshi, Terawaki Seigo, Shikina Takashi, Yamamoto Masafumi, Kurono Yuichi, Kiyono Hiroshi
発行年月	2002/07
概要	Initiation of nasopharyngeal-associated lymphoid tissue (NALT) development is independent of the programmed cytokine cascade necessary for the formation of Peyer's patches (PP) and peripheral lymph nodes (PLN), a cytokine cascade which consists of IL-7R, LTalpha1beta2/LTbetaR, and NIK. However, the subsequent organization of NALT seems to be controlled by these cytokine signaling cascades since the maturation of NALT structure is generally incomplete in those cytokine cascade-deficient mice. NALT as well as PP and PLN are completely absent in Id2(-/-) mice. NALT organogenesis is initiated following the adoptive transfer of CD3(-)CD4(+)CD45(+) cells into Id2(-/-) mice, constituting direct evidence that CD3(-)CD4(+)CD45(+) inducer cells can provide an IL-7R-, LTalpha1beta2/LTbetaR-, and NIK-independent tissue organogenesis pathway for secondary lymphoid tissue development.
DOI	10.1016/s1074-7613(02)00339-4
PMID	12150889