スギモト　ケン   Ken Sugimoto   杉本　研    所属   川崎医科大学  医学部 臨床医学　総合老年医学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Hyperglycemia in non-obese patients with type 2 diabetes is associated with low muscle mass: The Multicenter Study for Clarifying Evidence for Sarcopenia in Patients with Diabetes Mellitus.
掲載誌名	正式名：Journal of diabetes investigation 略　 称：J Diabetes Investig ISSNコード：20401124/20401116
掲載区分	国外
巻・号・頁	10(6),pp.1471-1479
著者・共著者	Sugimoto Ken, Tabara Yasuharu, Ikegami Hiroshi, Takata Yasunori, Kamide Kei, Ikezoe Tome, Kiyoshige Eri, Makutani Yukako, Onuma Hiroshi, Gondo Yasuyuki, Ikebe Kazunori, Ichihashi Noriaki, Tsuboyama Tadao, Matsuda Fumihiko, Kohara Katsuhiko, Kabayama Mai, Fukuda Masahiro, Katsuya Tomohiro, Osawa Haruhiko, Hiromine Yoshihisa, Rakugi Hiromi
発行年月	2019/11
概要	AIMS/INTRODUCTION:Hyperglycemia is a risk factor for sarcopenia when comparing individuals with and without diabetes. However, no studies have investigated whether the findings could be extrapolated to patients with diabetes with relatively higher glycemic levels. Here, we aimed to clarify whether glycemic control was associated with sarcopenia in patients with type 2 diabetes.MATERIALS AND METHODS:Study participants consisted of patients with type 2 diabetes (n = 746, the average age was 69.9 years) and an older general population (n = 2,067, the average age was 68.2 years). Sarcopenia was defined as weak grip strength or slow usual gait speed and low skeletal mass index.RESULTS:Among patients with type 2 diabetes, 52 were diagnosed as having sarcopenia. The frequency of sarcopenia increased linearly with glycated hemoglobin (HbA1c) level, particularly in lean individuals (HbA1c <6.5%, 7.0%, ≥6.5% and <7.0%: 18.5%; HbA1c ≥7.0% and <8.0%: 20.3%; HbA1c ≥8.0%: 26.7%). The linear association was independent of major covariates, including anthropometric factors and duration of diabetes (HbA1c <6.5%: reference; ≥6.5% and <7.0%: odds ratio [OR] 4.38, P = 0.030; HbA1c ≥7.0% and <8.0%: 4.29, P = 0.024; HbA1c ≥8.0%: 7.82, P = 0.003). HbA1c level was specifically associated with low skeletal mass index (HbA1c ≥8.0%: OR 5.42, P < 0.001) rather than weak grip strength (OR 1.89, P = 0.058) or slow gait speed (OR 1.13, P = 0.672). No significant association was observed in the general population with a better glycemic profile.CONCLUSIONS:Poor glycemic control in patients with diabetes was associated with low muscle mass.
DOI	10.1111/jdi.13070
PMID	31074209