Ken Sugimoto    Department   Kawasaki Medical School  Kawasaki Medical School, Department of General Geriatric Medicine,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Serum albumin/globulin ratio is associated with cognitive function in community-dwelling older people: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study.
Journal	Formal name：Geriatrics & gerontology international Abbreviation：Geriatr Gerontol Int ISSN code：14470594/14470594
Domestic / Foregin	Foregin
Volume, Issue, Page	19(10),pp.967-971
Author and coauthor	Maeda Satomi, Takeya Yasushi, Oguro Ryosuke, Akasaka Hiroshi, Ryuno Hirochika, Kabayama Mai, Yokoyama Serina, Nagasawa Motonori, Fujimoto Taku, Takeda Masao, Onishi-Takeya Miyuki, Itoh Norihisa, Takami Yoichi, Yamamoto Koichi, Sugimoto Ken, Inagaki Hiroki, Ogawa Madoka, Nakagawa Takeshi, Yasumoto Saori, Masui Yukie, Arai Yasumichi, Ishizaki Tatsuro, Ikebe Kazunori, Gondo Yasuyuki, Kamide Kei, Rakugi Hiromi
Publication date	2019/10
Summary	AIM:The objective of this study was to clarify the relationship between cognitive function and the serum albumin/globulin ratio (A/G ratio) in community-dwelling Japanese older adults.METHODS:Randomly extracted residents in both urban and rural parts of Japan were enrolled in this study. A total of 1827 participants with a mean age of 70 or 80 years were recruited. A venue survey method was carried out with comprehensive studies, including interviews, blood collection, physical examination and cognitive function tests.RESULTS:Univariate analysis showed a significant positive correlation between the total Japanese version of the Montreal Cognitive Assessment score and the serum A/G ratio at the age of 70 and 80 years, in which better cognitive function was associated with a high serum A/G ratio. Multiple regression analysis with the total Japanese version of the Montreal Cognitive Assessment score as the dependent variable showed that the serum albumin level, serum globulin level, serum A/G ratio, C-reactive protein, years of formal education and sex were related to the Japanese version of the Montreal Cognitive Assessment total score at the age of 70 years, and that the serum albumin level, serum globulin level, serum A/G ratio, C-reactive protein, years of formal education and stroke were related at the age of 80 years. The serum A/G ratio showed a better correlation than the serum globulin levels at the age of 70 and 80 years (70 years: β = 0.131 vs -0.111, 80 years: β = 0.108 vs -0.071).CONCLUSIONS:We found a correlation between cognitive function and the serum A/G ratio in community-dwelling older people, suggesting that nutritional status and chronic inflammation might influence cognitive function. Geriatr Gerontol Int 2019; 19: 967-971.
DOI	10.1111/ggi.13751
PMID	31461209