スギモト　ケン   Ken Sugimoto   杉本　研    所属   川崎医科大学  医学部 臨床医学　総合老年医学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	High plasma adiponectin levels are associated with frailty in a general old-old population: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study.
掲載誌名	正式名：Geriatrics & gerontology international 略　 称：Geriatr Gerontol Int ISSNコード：14470594/14470594
掲載区分	国外
巻・号・頁	18(6),pp.839-846
著者・共著者	Nagasawa Motonori, Takami Yoichi, Akasaka Hiroshi, Kabayama Mai, Maeda Satomi, Yokoyama Serina, Fujimoto Taku, Nozato Yoichi, Imaizumi Yuki, Takeda Masao, Itoh Norihisa, Takeya Yasushi, Yamamoto Koichi, Sugimoto Ken, Nakagawa Takeshi, Masui Yukie, Arai Yasumichi, Ishizaki Tatsuro, Ikebe Kazunori, Gondo Yasuyuki, Kamide Kei, Rakugi Hiromi
発行年月	2018/06
概要	AIM:The objective of the present study was to investigate the association between frailty and plasma adiponectin levels in a general population of Japanese older adults.METHODS:The volunteer older adults, aged approximately 83 years, were recruited randomly from a general population in the Japanese Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. We used the modified Cardiovascular Health Study criteria to assess the frailty status of the study participants. The study participants were classified as non-frail, pre-frail and frail according to their physical activities. We compared plasma adiponectin levels among these three groups and applied a multivariate logistic regression analysis including plasma adiponectin levels to clarify the factors associated with frailty status in the cross-sectional design.RESULTS:The mean age of the participants was 83.1 ± 0.9 years, and 51.8% were men. The frailty index was available to assess 353 participants, of whom 24.6% were classified as non-frail, 62.3% as prefrail and 13.0% as frail. The log-transformed plasma adiponectin levels increased stepwise in the following order: non-frail, pre-frail and frail. A multivariate logistic regression analysis showed that higher plasma adiponectin levels, a higher estimated glomerular filtration rate and lower hemoglobin levels were independent determinants for pre-frail/frail status compared with non-frail status.CONCLUSIONS:The present study showed that higher plasma adiponectin levels were associated with frailty status in older Japanese adults in the general population. Further longitudinal study is essential to clarify the role of plasma adiponectin in the progression of frailty. Geriatr Gerontol Int 2018; 18: 839-846.
DOI	10.1111/ggi.13258
PMID	29392822