スギモト　ケン   Ken Sugimoto   杉本　研    所属   川崎医科大学  医学部 臨床医学　総合老年医学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	A klotho gene single nucleotide polymorphism is associated with the onset of stroke and plasma klotho concentration.
掲載誌名	正式名：Aging 略　 称：Aging (Albany NY) ISSNコード：19454589/19454589
掲載区分	国外
巻・号・頁	11(1),pp.104-114
著者・共著者	Yokoyama Serina, Oguro Ryosuke, Yamamoto Koichi, Akasaka Hiroshi, Ito Norihisa, Kawai Tatsuo, Kusunoki Hiroshi, Takeya Yasushi, Takeya-Onishi Miyuki, Yamamoto-Hanasaki Hiroko, Sugimoto Ken, Ikebe Kazunori, Gondo Yasuyuki, Ohishi Mitsuru, Kamide Kei, Rakugi Hiromi
発行年月	2018/12
概要	Klotho protects against development of multiple age-related disorders, including cardiovascular diseases. We assessed whether a human klotho single nucleotide polymorphism (SNP) rs650439 is associated with the onset of stroke in hypertensive patients and plasma klotho concentration in the general population. Five hundred and twenty-three patients with hypertension were analyzed for both the presence of rs650439 and onset of stroke. We found that hypertensive patients with the TT genotype of rs650439 (n=52) had a higher incidence of stroke than those with AT (n=257) and AA (n=214) genotypes. Multivariate analysis indicated that the TT genotype was the only risk factor associated with increased incidence of stroke. Plasma klotho concentrations were measured in a general population (age=70±1 years) to assess the association between rs650439 and plasma klotho concentration. A significant trend was observed in the elderly population where plasma klotho concentration decreased as the T alleles in rs650439 increased. Subjects with a TT genotype had lower plasma klotho concentrations than those with AT+AA genotypes. In conclusion, TT genotype of klotho SNP (rs650439) is correlated with an increased incidence of stroke in hypertensive patients, and the mechanism underlying this correlation might involve the effect of rs650439 T allele on plasma klotho concentrations.
DOI	10.18632/aging.101728
PMID	30595559