スギモト　ケン   Ken Sugimoto   杉本　研    所属   川崎医科大学  医学部 臨床医学　総合老年医学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Occlusal force is correlated with cognitive function directly as well as indirectly via food intake in community-dwelling older Japanese: From the SONIC study.
掲載誌名	正式名：PloS one 略　 称：PLoS One ISSNコード：19326203/19326203
掲載区分	国外
巻・号・頁	13(1),pp.e0190741
著者・共著者	Ikebe Kazunori, Gondo Yasuyuki, Kamide Kei, Masui Yukie, Ishizaki Taturo, Arai Yasumichi, Inagaki Hiroki, Nakagawa Takeshi, Kabayama Mai, Ryuno Hirochika, Okubo Hitomi, Takeshita Hajime, Inomata Chisato, Kurushima Yuko, Mihara Yusuke, Hatta Kohdai, Fukutake Motoyoshi, Enoki Kaori, Ogawa Taiji, Matsuda Ken-Ichi, Sugimoto Ken, Oguro Ryosuke, Takami Yoichi, Itoh Norihisa, Takeya Yasushi, Yamamoto Koichi, Rakugi Hiromi, Murakami Shinya, Kitamura Masahiro, Maeda Yoshinobu
発行年月	2018/01
概要	BACKGROUND:Growing evidence suggests that oral health may be an important factor associated with cognitive function in aged populations. However, many previous studies on this topic used insensitive oral indicators or did not include certain essential covariates. Thus, we examined the association between occlusal force and cognitive function in a large sample of older adults, controlling for dietary intake, vascular risk factors, inflammatory biomarkers, depression, and genetic factors.METHODS:In this cross-sectional study of older community-dwelling Japanese adults, we examined data collected from 994 persons aged 70 years and 968 persons aged 80 years. Cognitive function was measured using the Japanese version of the Montreal Cognitive Assessment (MoCA-J). Oral status and function were evaluated according to the number of remaining teeth, periodontal pocket depth, and maximal occlusal force. Associations between MoCA-J scores and occlusal force were investigated via bivariate and multivariate analyses.RESULTS:Education level, financial status, depression score, and intake of green and yellow vegetables, as well as number of teeth and occlusal force, were significantly correlated with MoCA-J scores in both age groups. Among individuals aged 80 years, CRP and periodontal status were weakly but significantly associated with MoCA-J score. After controlling for all significant variables via bivariate analyses, the correlation between maximal occlusal force and cognitive function persisted. A path analysis confirmed the hypothesis that cognitive function is associated with occlusal force directly as well as indirectly via food intake.CONCLUSIONS:After controlling for possible factors, maximal occlusal force was positively associated with cognitive function directly as well as indirectly through dietary intake.
DOI	10.1371/journal.pone.0190741
PMID	29304177