Ken Sugimoto    Department   Kawasaki Medical School  Kawasaki Medical School, Department of General Geriatric Medicine,    Position   Professor
Article types	原著
Language	English
Peer review	Non peer reviewed
Presence of invitation	Invited paper
Title	Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice.
Journal	Formal name：Scientific reports Abbreviation：Sci Rep ISSN code：20452322/20452322
Domestic / Foregin	Foregin
Volume, Issue, Page	7,pp.42323
Author and coauthor	Takeshita Hikari, Yamamoto Koichi, Nozato Satoko, Inagaki Tadakatsu, Tsuchimochi Hirotsugu, Shirai Mikiyasu, Yamamoto Ryohei, Imaizumi Yuki, Hongyo Kazuhiro, Yokoyama Serina, Takeda Masao, Oguro Ryosuke, Takami Yoichi, Itoh Norihisa, Takeya Yasushi, Sugimoto Ken, Fukada So-Ichiro, Rakugi Hiromi
Publication date	2017/02
Summary	The conventional forelimb grip strength test is a widely used method to assess skeletal muscle function in rodents; in this study, we modified this method to improve its variability and consistency. The modified test had lower variability among trials and days than the conventional test in young C57BL6 mice, especially by improving the variabilities in male. The modified test was more sensitive than the conventional test to detect a difference in motor function between female and male mice, or between young and old male mice. When the modified test was performed on male mice during the aging process, reduction of grip strength manifested between 18 and 24 months of age at the group level and at the individual level. The modified test was similar to the conventional test in detecting skeletal muscle dysfunction in young male dystrophic mice. Thus, the modified forelimb grip strength test, with its improved validity and reliability may be an ideal substitute for the conventional method.
DOI	10.1038/srep42323
PMID	28176863