スギモト　ケン   Ken Sugimoto   杉本　研    所属   川崎医科大学  医学部 臨床医学　総合老年医学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読なし
招待の有無	招待あり
表題	Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice.
掲載誌名	正式名：Scientific reports 略　 称：Sci Rep ISSNコード：20452322/20452322
掲載区分	国外
巻・号・頁	7,pp.42323
著者・共著者	Takeshita Hikari, Yamamoto Koichi, Nozato Satoko, Inagaki Tadakatsu, Tsuchimochi Hirotsugu, Shirai Mikiyasu, Yamamoto Ryohei, Imaizumi Yuki, Hongyo Kazuhiro, Yokoyama Serina, Takeda Masao, Oguro Ryosuke, Takami Yoichi, Itoh Norihisa, Takeya Yasushi, Sugimoto Ken, Fukada So-Ichiro, Rakugi Hiromi
発行年月	2017/02
概要	The conventional forelimb grip strength test is a widely used method to assess skeletal muscle function in rodents; in this study, we modified this method to improve its variability and consistency. The modified test had lower variability among trials and days than the conventional test in young C57BL6 mice, especially by improving the variabilities in male. The modified test was more sensitive than the conventional test to detect a difference in motor function between female and male mice, or between young and old male mice. When the modified test was performed on male mice during the aging process, reduction of grip strength manifested between 18 and 24 months of age at the group level and at the individual level. The modified test was similar to the conventional test in detecting skeletal muscle dysfunction in young male dystrophic mice. Thus, the modified forelimb grip strength test, with its improved validity and reliability may be an ideal substitute for the conventional method.
DOI	10.1038/srep42323
PMID	28176863