スギモト　ケン   Ken Sugimoto   杉本　研    所属   川崎医科大学  医学部 臨床医学　総合老年医学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Relationship between renal hemodynamic status and aging in patients without diabetes evaluated by renal Doppler ultrasonography.
掲載誌名	正式名：Clinical and experimental nephrology 略　 称：Clin Exp Nephrol ISSNコード：14377799/13421751
掲載区分	国外
巻・号・頁	16(5),pp.786-791
著者・共著者	Kawai Tatsuo, Kamide Kei, Onishi Miyuki, Hongyo Kazuhiro, Yamamoto-Hanasaki Hiroko, Oguro Ryosuke, Maekawa Yoshihiro, Yamamoto Koichi, Takeya Yasushi, Sugimoto Ken, Ohishi Mitsuru, Rakugi Hiromi
発行年月	2012/10
概要	BACKGROUND:Aging is well known as one of the major causes of a reduced glomerular filtration rate (GFR). The resistive index (RI) measured by renal Doppler ultrasonography (RDU) is thought to be a good indicator of renal vascular resistance induced by arteriosclerosis. In this study, we investigated whether RI could be used to evaluate the pathogenesis of renal damage or the mechanisms of reduction of renal function by aging.METHODS:We investigated the correlation between RI and multiple clinical parameters and the influence of aging on the renal hemodynamic status of 194 in-patients (mean age 66.2 years) who underwent RDU at our hospital between February 2009 and July 2010.RESULTS:RI was significantly correlated with the age, estimated GFR (eGFR), diastolic blood pressure, pulse pressure, and degree of albuminuria. Subjects aged ≥75 years showed a significantly higher correlation coefficient between eGFR and RI. RI showed a stronger correlation with age in subjects aged ≥75 years compared to eGFR.CONCLUSION:The present study showed that renal vascular resistance and intra-renal arteriosclerosis had a greater impact on renal function in older than younger subjects, reflecting the possible mechanisms of renal function reduction due to aging.
DOI	10.1007/s10157-012-0627-1
PMID	22492010