スギモト　ケン   Ken Sugimoto   杉本　研    所属   川崎医科大学  医学部 臨床医学　総合老年医学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Hypoadiponectinemia is an independent risk factor for hypertension.
掲載誌名	正式名：Hypertension (Dallas, Tex. : 1979) 略　 称：Hypertension ISSNコード：15244563/0194911X
掲載区分	国外
巻・号・頁	43(6),pp.1318-1323
著者・共著者	Iwashima Yoshio, Katsuya Tomohiro, Ishikawa Kazuhiko, Ouchi Noriyuki, Ohishi Mitsuru, Sugimoto Ken, Fu Yuxiao, Motone Masaharu, Yamamoto Kouichi, Matsuo Akiko, Ohashi Koji, Kihara Shinji, Funahashi Tohru, Rakugi Hiromi, Matsuzawa Yuji, Ogihara Toshio
発行年月	2004/06
概要	Adiponectin is one of the key molecules in the metabolic syndrome, and its concentration is decreased in obesity, type-2 diabetes, and coronary artery disease. Genetic investigation has revealed that 2 polymorphisms (I164T and G276T) are related to adiponectin concentration and diabetes. To examine whether adiponectin affects hypertension genetically or biologically, we performed a case-control study. A total of 446 diagnosed cases of hypertension (HT) in men and 312 normotensive (NT) men were enrolled in this study. Plasma adiponectin concentration was measured using an enzyme-linked immunosorbent assay system. Single nucleotide polymorphisms were determined by TaqMan polymerase chain reaction method. After adjustment for confounding factors, adiponectin concentration was significantly lower in HT (HT: 5.2+/-0.2 microg/mL; NT: 6.1+/-0.2 microg/mL; P<0.001). Furthermore, multiple regression analysis indicated that hypoadiponectinemia was an independent risk factor for hypertension (P<0.001). Blood pressure was inversely associated with adiponectin concentration in normotensives regardless of insulin resistance. In subjects carrying the TC genotype of the I164T polymorphism, adiponectin concentration was significantly lower (TC: 2.6+/-0.9 microg/mL; TT: 5.5+/-0.1 microg/mL; P<0.01), and most of them had hypertension. In contrast, the G276T polymorphism was not associated with adiponectin concentration or hypertension. In conclusion, hypoadiponectinemia is a marker for predisposition to hypertension in men.
DOI	10.1161/01.HYP.0000129281.03801.4b
PMID	15123570