Ken Sugimoto
   Department   Kawasaki Medical School  Kawasaki Medical School, Department of General Geriatric Medicine,
   Position   Professor
Article types 原著
Language English
Peer review Peer reviewed
Title Association between hepatocyte growth factor gene polymorphism and essential hypertension.
Journal Formal name：Hypertension research : official journal of the Japanese Society of Hypertension
Abbreviation：Hypertens Res
ISSN code：09169636/09169636
Domestic / ForeginForegin
Volume, Issue, Page 27(4),pp.247-251
Author and coauthor Motone Masaharu, Katsuya Tomohiro, Ishikawa Kazuhiko, Iwashima Yoshio, Sugimoto Ken, Yamamoto Koichi, Fu Yuxiao, Matsuo Akiko, Ohishi Mitsuru, Rakugi Hiromi, Ogihara Toshio
Publication date 2004/04
Summary Hepatocyte growth factor (HGF) is a growth factor which contributes to protection and/or repair of vascular endothelial cells. Serum HGF level is elevated in response to hypertensive organ damage, which suggests that blood pressure regulation may be affected by HGF gene polymorphisms via serum HGF. To examine the interaction between a HGF gene polymorphism and hypertension, we carried out a case-control study. The present study was conducted in outpatients of Osaka University Hospital. Subjects (n=654) who gave informed consent to the study protocol and genetic analysis were recruited. A C to A nucleotide substitution in intron 13 of the HGF gene was determined by the TaqMan polymerase chain reaction (PCR) method using an MGB (Minor Groove Binder) probe. The genotype distribution of the C/A polymorphism of the HGF gene in total subjects was as follows: CC, 83%; CA, 16%; and AA 1%. This distribution was not significantly different from the predicted by Hardy-Weinberg's equilibrium. The prevalence of hypertension was significantly higher in subjects with the CC genotype than in those with an A allele, and the positive association remained after adjustment for confounding factors, with the estimated odds ratio for hypertension (CC vs. CA+AA) being 1.71 (95% confidence interval: 1.02-2.93). A significant association with hypertension was observed in lean or female subjects but not in obese or male subjects. In conclusion, our data suggested that C/A polymorphism in intron 13 of the HGF gene is associated with susceptibility to essential hypertension in lean or female subjects.
DOI 10.1291/hypres.27.247
PMID 15127882