Atsushi Fujiwara    Department   Kawasaki University of Medical Welfare  ,    Position   Assistant Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Results of a Treat-and-Eextend Regimen of Intravitreal Ranibizumab Injection for Macular Edema due to Branch Retinal Vein Occlusion.
Journal	Formal name：Acta medica Okayama Abbreviation：Acta Med Okayama ISSN code：0386300X/0386300X
Domestic / Foregin	Foregin
Volume, Issue, Page	72(1),pp.39-45
Author and coauthor	Hosogi Mika, Morizane Yuki, Shiode Yusuke, Doi Shinichiro, Kumase Fumiaki, Kimura Shuhei, Hosokawa Mio, Hirano Masayuki, Toshima Shinji, Takahashi Kosuke, Fujiwara Atsushi, Shiraga Fumio
Publication date	2018/02
Summary	To investigate the effectiveness of a treat-and-extend regimen (TAE) of intravitreal ranibizumab injections (IVR) for macular edema (ME) due to branch retinal vein occlusion (BRVO). We retrospectively examined 35 eyes of 35 patients with ME due to BRVO who underwent TAE for 1 year. Patients whose treatment interval extended to 12 weeks were switched to a pro re nata regimen (PRN; TAE to PRN group), while TAE was continued for patients whose treatment interval was less than 12 weeks (continued TAE group). Changes in best-corrected visual acuity (BCVA), central retinal thickness (CRT), and predictive factors for inclusion in the TAE to PRN group were analyzed. BCVA and CRT both improved significantly at 1 year compared with baseline (p<0.001). Sixteen eyes (45.7%) were included in the TAE to PRN group, while 19 eyes (54.3%) were included in the continued TAE group. BCVA in the TAE to PRN group was significantly better than that in the continued TAE group at 1 year (p=0.047). BCVA at baseline and macular BRVO were significant predictive factors for inclusion in the TAE to PRN group. TAE was effective for improving BCVA and CRT. The TAE to PRN group showed significantly better prognosis.
DOI	10.18926/AMO/55661
PMID	29463937