フジワラ アツシ
  藤原 篤之
   所属   川崎医療福祉大学  リハビリテーション学部 視能療法学科
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Retinal sensitivity after displacement of submacular hemorrhage due to polypoidal choroidal vasculopathy: effectiveness and safety of subretinal tissue plasminogen activator.
掲載誌名 正式名:Japanese journal of ophthalmology
略  称:Jpn J Ophthalmol
ISSNコード:16132246/00215155
掲載区分国外
巻・号・頁 61(6),472-478頁
著者・共著者 Kimura Shuhei, Morizane Yuki, Matoba Ryo, Hosokawa Mio, Shiode Yusuke, Hirano Masayuki, Doi Shinichiro, Toshima Shinji, Takahashi Kosuke, Hosogi Mika, Fujiwara Atsushi, Shiraga Fumio
発行年月 2017/11
概要 PURPOSE:To investigate the effectiveness of displacement of submacular hemorrhage (SMH) caused by polypoidal choroidal vasculopathy (PCV) by assessing retinal sensitivity using microperimetry.METHODS:We retrospectively reviewed the medical records of 11 consecutive PCV patients with SMH. All patients underwent vitrectomy, subretinal injection of tissue plasminogen activator, and fluid-air exchange, followed by antivascular endothelial growth factor therapy using a pro re nata regimen. The retinal sensitivity was measured by use of microperimetry before and after surgery.RESULTS:The mean (SD) age of the patients was 74.1 ± 9.4 years. The mean SMH diameter was 6.8 ± 5.2 disc diameters. The best-corrected visual acuity (BCVA), mean retinal sensitivity, and mean number of measure points with a sensitivity ≥10 dB before the surgery were 0.94 ± 0.49, 4.2 ± 4.5 dB, and 15.6 ± 15.1 points, respectively. These had significantly improved 6 months after surgery (0.39 ± 0.37, 15.6 ± 7.3 dB, and 50.9 ± 22.2 points, respectively; P < 0.05 for all outcome measures). The mean number of measure points with an absolute scotoma before surgery had decreased significantly 6 months after surgery (from 40.5 ± 15.0 to 9.4 ± 16.0 points; P < 0.001).CONCLUSIONS:Displacement of SMH effectively improves retinal sensitivity as well as BCVA.
DOI 10.1007/s10384-017-0530-0
PMID 28836011