藤原 篤之
   Department     ,
   Position  
Article types 原著
Language English
Peer review Peer reviewed
Title Relationship between progression of visual field damage and choroidal thickness in eyes with normal-tension glaucoma.
Journal Formal name:Clinical & experimental ophthalmology
Abbreviation:Clin Exp Ophthalmol
ISSN code:14429071/14426404
Domestic / ForeginForegin
Volume, Issue, Page 40(6),576-582頁
Author and coauthor Hirooka Kazuyuki, Fujiwara Atsushi, Shiragami Chieko, Baba Tetsuya, Shiraga Fumio
Publication date 2012/08
Summary BACKGROUND:  To measure choroidal thickness in normal eyes and in patients with normal-tension glaucoma using enhanced depth imaging optical coherence tomography and evaluate the association between choroidal thickness and progression of visual field damage.DESIGN:  Cross-sectional comparative study.PARTICIPANTS:  A total of 62 eyes of 62 normal subjects and 45 eyes of 45 normal-tension glaucoma patients were examined.METHODS:  The choroid was measured at the fovea and 3 mm nasal and temporal from the fovea. In the separate study, both eyes of the patients with normal-tension glaucoma were included in the analyses. Visual fields were measured with automated perimetry. Changes in mean deviation per year (dB/year), that is, mean deviation slope, were calculated.MAIN OUTCOME MEASURES:  Difference in the choroidal thickness between the normal subjects and the patients with normal-tension glaucoma. The relationship between mean deviation slope and the choroidal thickness in eyes with normal-tension glaucoma was analysed.RESULTS:  Compared with normal subjects, the choroidal thickness was significantly thinner in eyes with normal-tension glaucoma at 3 mm nasal from the fovea (P = 0.02). There was a significant correlation between the choroidal thickness at 3 mm nasal from the fovea and the mean deviation slope (Pearson's r = 0.413; P < 0.001).CONCLUSION:  The decrease in the thickness of the choroid at 3 mm nasal from the fovea in eyes with normal-tension glaucoma may be associated with progressive visual field loss. Thus, choroidal abnormalities may play a role in the pathogenesis of normal-tension glaucoma.
DOI 10.1111/j.1442-9071.2012.02762.x
PMID 22300430