フジワラ　アツシ   Atsushi Fujiwara   藤原　篤之    所属   川崎医療福祉大学  リハビリテーション学部 視能療法学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	One-year results of bevacizumab intravitreal and posterior sub-Tenon injection of triamcinolone acetonide with reduced laser fluence photodynamic therapy for retinal angiomatous proliferation.
掲載誌名	正式名：Japanese journal of ophthalmology 略　 称：Jpn J Ophthalmol ISSNコード：16132246/00215155
掲載区分	国外
巻・号・頁	56(6),pp.599-607
著者・共著者	Shirakata Yukari, Shiragami Chieko, Yamashita Ayana, Nitta Eri, Fujiwara Atsushi, Shiraga Fumio
発行年月	2012/11
概要	PURPOSE:Our aim was to study the efficacy of combined triple therapy with intravitreal bevacizumab injections (IVB), posterior sub-Tenon injection of triamcinolone acetonide (STTA), and reduced laser fluence photodynamic therapy (RFPDT) in Japanese patients with retinal angiomatous proliferation (RAP).DESIGN:This was a retrospective, observational, consecutive case series.METHODS:Fifteen consecutive RAP treatment-naïve eyes were treated with triple therapy of IVB, STTA, and RFPDT (25 J/cm(2) of laser fluence). Whenever there was a recurrence of retinal-retinal anastomosis (RRA) or retinal-choroidal anastomosis (RCA) and marked leakage from subretinal neovascularization, the triple therapy was reapplied. When there were only intraretinal exudative and/or hemorrhagic changes without distinct RRA or RCA, IVB alone was applied.RESULTS:The mean logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA) at baseline improved significantly (from 0.489 to 0.294 12 months) (paired t test, p = 0.043). LogMAR BCVA at 12 months was stable or improved by ≥ 0.2 in 14 eyes (93.3 %). Mean number of triple therapy instituted during the 12-month study period was 1.2, and mean number of IVB treatments was 1.4.CONCLUSION:Combined IVB, STTA, and RFPDT for RAP was effective in maintaining or improving VA at 1 year. In addition, the number of treatments could be markedly reduced.
DOI	10.1007/s10384-012-0183-y
PMID	22990616