Nagio Takigawa    Department   Kawasaki Medical School  Kawasaki Medical School, Department of General Internal Medicine 4,    Position   Professor
Article types	症例報告
Language	English
Peer review	Peer reviewed
Title	Disappearance of an activated EGFR mutation after treatment with EGFR tyrosine kinase inhibitors
Journal	Formal name：Lung cancer Abbreviation：Lung cancer
Volume, Issue, Page	78(1),pp.121-124
Author and coauthor	Honda Yoshihiro, Takigawa Nagio, Fushimi Soichiro, Ochi Nobuaki, Kubo Toshio, Ozaki Saeko, Tanimoto Mitsune, Kiura Katsuyuki
Authorship	2nd author,Corresponding author
Publication date	2012/10
Summary	A 34-year-old Japanese woman presented with left supraclavicular lymph node swelling. Computed tomography scans revealed a mass on the left lower lobe, pulmonary nodules, and pleural effusion. A lymph node biopsy revealed large-cell carcinoma with an epidermal growth factor receptor (EGFR) deletion mutation, L747-T751 in exon 19. Although malignant pleural effusions carried the same EGFR mutation, progressive pleural effusions after treatment with chemotherapy, gefitinib, and erlotinib did not show any EGFR mutation. A cell line established from the pleural effusion 3 days before the patient expired also did not harbor the EGFR mutation. Histological sections of the lymph node of the patient were similar to those of the xenograft tumor of the cell line. There may be genetic heterogeneity in EGFR mutant tumors.
DOI	10.1016/j.lungcan.2012.07.003
Document No.	22835516