タキガワ ナギオ
  瀧川 奈義夫
   所属   川崎医科大学  医学部 臨床医学 総合内科学4
   職種   教授
論文種別 症例報告
言語種別 英語
査読の有無 査読あり
表題 Disappearance of an activated EGFR mutation after treatment with EGFR tyrosine kinase inhibitors
掲載誌名 正式名:Lung cancer
略  称:Lung cancer
巻・号・頁 78(1),121-124頁
著者・共著者 Honda Yoshihiro, Takigawa Nagio, Fushimi Soichiro, Ochi Nobuaki, Kubo Toshio, Ozaki Saeko, Tanimoto Mitsune, Kiura Katsuyuki
発行年月 2012/10
概要 A 34-year-old Japanese woman presented with left supraclavicular lymph node swelling. Computed tomography scans revealed a mass on the left lower lobe, pulmonary nodules, and pleural effusion. A lymph node biopsy revealed large-cell carcinoma with an epidermal growth factor receptor (EGFR) deletion mutation, L747-T751 in exon 19. Although malignant pleural effusions carried the same EGFR mutation, progressive pleural effusions after treatment with chemotherapy, gefitinib, and erlotinib did not show any EGFR mutation. A cell line established from the pleural effusion 3 days before the patient expired also did not harbor the EGFR mutation. Histological sections of the lymph node of the patient were similar to those of the xenograft tumor of the cell line. There may be genetic heterogeneity in EGFR mutant tumors.
DOI 10.1016/j.lungcan.2012.07.003
文献番号 22835516