ワタナベ ヨシコ   Yoshiko Watanabe
  渡部 芳子
   所属   川崎医科大学  医学部 臨床医学 総合臨床医学
   職種   講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Organ Damage and Quality of Life in Takayasu Arteritis - Evidence From a National Registry Analysis.
掲載誌名 正式名:Circulation journal : official journal of the Japanese Circulation Society
略  称:Circ J
ISSNコード:13474820/13469843
掲載区分国外
巻・号・頁 22(88),pp.285-294
著者・共著者 Hajime Yoshifuji, Yoshikazu Nakaoka, Haruhito A Uchida, Takahiko Sugihara, Yoshiko Watanabe, Sohei Funakoshi, Mitsuaki Isobe, Masayoshi Harigai,
発行年月 2023/12
概要 BACKGROUND:Takayasu arteritis, affecting primarily young women, damages large arteries and organs. We examined the impact of disease duration and sex on organ damage and quality of life using Japan's Intractable Disease Registry.Methods and Results: After refining data, 2,013 of 2,795 patients were included in the study. Longer disease duration was related to a lower prevalence of disease activity symptoms, a higher prevalence of organ damage, and a higher proportion of patients requiring nursing care. Compared with men, women tended to have an earlier onset age, exhibiting longer disease duration. A higher proportion of women had aortic regurgitation and required nursing care. The proportion of female patients in employment was lower than that of the general female population, whereas no difference was observed between male patients and the general male population. Logistic regression analysis revealed that age at surveillance, brain ischemia, visual impairment/loss, and ischemic heart disease were significant factors associated with high nursing care needs (Level ≥2, with daily activity limitations).CONCLUSIONS:Early diagnosis and effective treatment, particularly to prevent brain ischemia, visual impairment, and ischemic heart disease, may improve the quality of life of patients with Takayasu arteritis, especially women.
DOI 10.1253/circj.CJ-23-0656
PMID 38123296