Fukushima Yasuhiro    Department   Kawasaki University of Medical Welfare  ,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Input integration around the dendritic branches in hippocampal dentate granule cells
Journal	Formal name：Cognitive Neurodynamics ISSN code：18714080
Publisher	Springer Verlag
Volume, Issue, Page	8(4),pp.267-276
Author and coauthor	Tadanobu Chuyo Kamijo, Hirofumi Hayakawa, Yasuhiro Fukushima, Yoshiyuki Kubota, Yoshikazu Isomura, Minoru Tsukada, Takeshi Aihara
Publication date	2014/08
Summary	Recent studies have shown that the dendrites of several neurons are not simple translators but are crucial facilitators of excitatory postsynaptic potential (EPSP) propagation and summation of synaptic inputs to compensate for inherent voltage attenuation. Granule cells (GCs)are located at the gateway for valuable information arriving at the hippocampus from the entorhinal cortex. However, the underlying mechanisms of information integration along the dendrites of GCs in the hippocampus are still unclear. In this study, we investigated the input integration around dendritic branches of GCs in the rat hippocampus. We applied differential spatiotemporal stimulations to the dendrites using a high-speed glutamate-uncaging laser. Our results showed that when two sites close to and equidistant from a branching point were simultaneously stimulated, a nonlinear summation of EPSPs was observed at the soma. In addition, nonlinear summation (facilitation) depended on the stimulus location and was significantly blocked by the application of a voltage-dependent Ca2+ channel antagonist. These findings suggest that the nonlinear summation of EPSPs around the dendritic branches of hippocampal GCs is a result of voltage-dependent Ca2+ channel activation and may play a crucial role in the integration of input information.