フクシマ ヤスヒロ   Fukushima Yasuhiro
  福島 康弘
   所属   川崎医療福祉大学  医療福祉学部 医療福祉学科
   職種   准教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Input integration around the dendritic branches in hippocampal dentate granule cells
掲載誌名 正式名:Cognitive Neurodynamics
ISSNコード:18714080
出版社 Springer Verlag
巻・号・頁 8(4),267-276頁
著者・共著者 Tadanobu Chuyo Kamijo, Hirofumi Hayakawa, Yasuhiro Fukushima, Yoshiyuki Kubota, Yoshikazu Isomura, Minoru Tsukada, Takeshi Aihara
発行年月 2014/08
概要 Recent studies have shown that the dendrites of several neurons are not simple translators but are crucial facilitators of excitatory postsynaptic potential (EPSP) propagation and summation of synaptic inputs to compensate for inherent voltage attenuation. Granule cells (GCs)are located at the gateway for valuable information arriving at the hippocampus from the entorhinal cortex. However, the underlying mechanisms of information integration along the dendrites of GCs in the hippocampus are still unclear. In this study, we investigated the input integration around dendritic branches of GCs in the rat hippocampus. We applied differential spatiotemporal stimulations to the dendrites using a high-speed glutamate-uncaging laser. Our results showed that when two sites close to and equidistant from a branching point were simultaneously stimulated, a nonlinear summation of EPSPs was observed at the soma. In addition, nonlinear summation (facilitation) depended on the stimulus location and was significantly blocked by the application of a voltage-dependent Ca2+ channel antagonist. These findings suggest that the nonlinear summation of EPSPs around the dendritic branches of hippocampal GCs is a result of voltage-dependent Ca2+ channel activation and may play a crucial role in the integration of input information.