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Fukushima Yasuhiro
Department Kawasaki University of Medical Welfare , Position Professor |
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| Article types | 原著 |
| Language | English |
| Peer review | Peer reviewed |
| Title | Spatiotemporal characteristics of synaptic EPSP summation on the dendritic trees of hippocampal CA1 pyramidal neurons as revealed by laser uncaging stimulation |
| Journal | Formal name：Cognitive Neurodynamics Abbreviation：Cogn. Neurodyn. ISSN code：18714080/18714099 |
| Volume, Issue, Page | 5(4),pp.333-342 |
| Author and coauthor | Makoto Yoneyama, Yasuhiro Fukushima, Minoru Tsukada, Takeshi Aihara |
| Authorship | 2nd author |
| Publication date | 2011/11 |
| Summary | Synaptic strength is modified by the temporal coincidence of synaptic inputs without back-propagating action potentials (BPAPs) in CA1 pyramidal neurons. In order to clarify the interactive mechanisms of associative long-term potentiation (LTP) without BPAPs, local paired stimuli were applied to the dendrites using high-speed laser uncaging stimulation equipment. When the spatial distance between the paired stimuli was <10 micrometer, nonlinear amplification in excitatory postsynaptic potential summation was observed. In the time window from −20 to 20 ms, supralinear amplification was observed. Supralinear amplification was modulated by antagonist of voltage-gated Na+/Ca2+ channels and NMDA-type glutamate receptors. These results are closely related to the spatiotemporal-characteristics of associative LTP without BPAPs. This study proposes an essential aspect of dendritic information processing. |
| DOI | 10.1007/s11571-011-9158-9 |