所属 川崎医療福祉大学 医療福祉学部 医療福祉学科 職種 准教授
|表題||Spatiotemporal characteristics of synaptic EPSP summation on the dendritic trees of hippocampal CA1 pyramidal neurons as revealed by laser uncaging stimulation|
略 称：Cogn. Neurodyn.
|著者・共著者||Makoto Yoneyama, Yasuhiro Fukushima, Minoru Tsukada, Takeshi Aihara|
|概要||Synaptic strength is modified by the temporal coincidence of synaptic inputs without back-propagating action potentials (BPAPs) in CA1 pyramidal neurons. In order to clarify the interactive mechanisms of associative long-term potentiation (LTP) without BPAPs, local paired stimuli were applied to the dendrites using high-speed laser uncaging stimulation equipment. When the spatial distance between the paired stimuli was <10 micrometer, nonlinear amplification in excitatory postsynaptic potential summation was observed. In the time window from −20 to 20 ms, supralinear amplification was observed. Supralinear amplification was modulated by antagonist of voltage-gated Na+/Ca2+ channels and NMDA-type glutamate receptors. These results are closely related to the spatiotemporal-characteristics of associative LTP without BPAPs. This study proposes an essential aspect of dendritic information processing.|