フクシマ　ヤスヒロ   Fukushima Yasuhiro   福島　康弘    所属   川崎医療福祉大学  医療福祉学部 医療福祉学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Spatiotemporal characteristics of synaptic EPSP summation on the dendritic trees of hippocampal CA1 pyramidal neurons as revealed by laser uncaging stimulation
掲載誌名	正式名：Cognitive Neurodynamics 略　 称：Cogn. Neurodyn. ISSNコード：18714080/18714099
巻・号・頁	5(4),pp.333-342
著者・共著者	Makoto Yoneyama, Yasuhiro Fukushima, Minoru Tsukada, Takeshi Aihara
担当区分	2nd著者
発行年月	2011/11
概要	Synaptic strength is modified by the temporal coincidence of synaptic inputs without back-propagating action potentials (BPAPs) in CA1 pyramidal neurons. In order to clarify the interactive mechanisms of associative long-term potentiation (LTP) without BPAPs, local paired stimuli were applied to the dendrites using high-speed laser uncaging stimulation equipment. When the spatial distance between the paired stimuli was <10 micrometer, nonlinear amplification in excitatory postsynaptic potential summation was observed. In the time window from −20 to 20 ms, supralinear amplification was observed. Supralinear amplification was modulated by antagonist of voltage-gated Na+/Ca2+ channels and NMDA-type glutamate receptors. These results are closely related to the spatiotemporal-characteristics of associative LTP without BPAPs. This study proposes an essential aspect of dendritic information processing.
DOI	10.1007/s11571-011-9158-9