Shigeki Ono    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Neurosurgery 2,    Position   Professor
Article types	原著
Language	English
Peer review	Non peer reviewed
Title	The vasorelaxation of cerebral arteries by carbon monoxide
Journal	Formal name：Experimental biology and medicine (Maywood, N.J.) Abbreviation：Exp Biol Med (Maywood) ISSN code：15353702/15353699
Volume, Issue, Page	226(9),pp.860-865
Author and coauthor	Komuro T, Borsody MK, Ono S, Marton LS, Weir BK, Zhang ZD, Paik E, Macdonald RL.
Publication date	2001/10
Summary	Carbon monoxide (CO) is known to increase cerebral blood flow, but the effect of CO on the vascular tone of large cerebral arteries is uncertain. We tested whether CO affects cerebral artery tone by measuring tension generated by ex vivo segments of dog basilar artery upon exposure to CO. In cerebral artery segments contracted with either KCl or prostaglandin F(2alpha), CO caused a concentration-related relaxation beginning with a concentration of 57 microM. Relaxation did not occur if CO was administered in the presence of bubbling carboxygen (95% O(2):5% CO(2)), which reduces greater than 99% of CO from the solution. Furthermore, the CO-induced relaxation of cerebral artery segments was reduced in the presence of the guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, 10 microM)or the potassium channel blocker tetraethylammonium (TEA, 1 mM). Neither ODQ nor TEA completely eliminated the relaxation caused by CO and there was no additive effect if ODQ and TEA were administered together. These results suggest that cerebral arteries are directly relaxed by CO and that this relaxation depends upon the activation of guanylyl cyclase and the opening of potassium channels.
Document No.	11568310