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Akira Yamauchi
Department Kawasaki Medical School Kawasaki Medical School, Department of Biochemistry, Position Professor |
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| Article types | 原著 |
| Language | English |
| Peer review | Peer reviewed |
| Title | Establishment of anti-DKK3 peptide for the cancer control in head and neck squamous cell carcinoma (HNSCC). |
| Journal | Formal name：Cancer Cell International Abbreviation：Cancer Cell Int. ISSN code：14752867 |
| Domestic / Foregin | Foregin |
| Publisher | Springer Nature. |
| Volume, Issue, Page | 22(1) |
| Author and coauthor | Katase N, Nishimatsu SI, Yamauchi A, Okano S, Fujita S. |
| Publication date | 2022/11/15 |
| Summary | Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor of the head and neck. We identified cancer-specific genes in HNSCC and focused on DKK3 expression. DKK3 gene codes two isoforms of proteins (secreted and non-secreted) with two distinct cysteine rich domains (CRDs). It is reported that DKK3 functions as a negative regulator of oncogenic Wnt signaling and, is therefore, considered to be a tumor suppressor gene. However, our series of studies have demonstrated that DKK3 expression is specifically high in HNSCC tissues and cells, and that DKK3 might determine the malignant potentials of HNSCC cells via the activation of Akt. Further analyses strongly suggested that both secreted DKK3 and non-secreted DKK3 could activate Akt signaling in discrete ways, and consequently exert tumor promoting effects. We hypothesized that DKK3 might be a specific druggable target, and it is necessary to establish a DKK3 inhibitor that can inhibit both secreted and non-secreted isoforms of DKK3. |
| DOI | 10.1186/s12935-022-02783-9 |
| PMID | 36376957 |
| URL for researchmap | https://doi.org/10.1186/s12935-022-02783-9 |