Akira Yamauchi    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Biochemistry,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Synthesis of 4-aroyl-5-arylpyrazoles and 4-aroyl-3-arylpyrazoles via the reaction of enaminodiketones with substituted hydrazines
Journal	Formal name：Heterocycles Abbreviation：Heterocycles ISSN code：03855414
Domestic / Foregin	Foregin
Publisher	The Japan Institute of Heterocyclic Chemistry
Volume, Issue, Page	100(1),pp.25-45
Total page number	21
Author and coauthor	Rika Kotouge, Takashi Nishiyama, Akira Yamauchi, Kanako Ono, Noriyuki Hatae, Tsutomu Oikawa, Satoshi Hibino, and Tominari Choshi
Publication date	2020
Summary	Pyrazole is a five-membered heterocyclic compound and is one of the important heterocycles in the fields of medicine and pharmacology. Here, we demonstrate the reactivity of symmetrical enaminodiketones 8–14 with substituted hydrazines. When using alkylhydrazines, if the substituent size of the alkyl group is small, it is possible to selectively synthesize 1-substituted 4-aroyl-5-arylpyrazoles and their regioisomers, 1-substituted 4-aroyl-3-arylpyrazoles, by choosing the solvent (EtOH or toluene). When they react with bulky substituted hydrazines (e.g., cyclohexyl, phenyl, or pyridyl), only 1-substituted 4-aroyl-5-arylpyrazoles are selectively obtained.
DOI	10.3987/COM-19-14096