Keita Sato
   Department   Kawasaki Medical School  Kawasaki Medical School, Department of Anatomy,
   Position   Instructor
Article types 原著
Language English
Peer review Peer reviewed
Title Variations in GABA immunoreactivity among granule cells of the mouse olfactory bulb, as revealed by high-voltage electron microscopy.
Journal Formal name：Neuroscience letters
Abbreviation：Neurosci Lett
ISSN code：18727972/03043940
Domestic / ForeginForegin
Volume, Issue, Page 738,pp.135386
Author and coauthor Satoh Keita, Kiyokage Emi, Ichikawa Satoshi, Toida Kazunori
Authorship Lead author
Publication date 2020/09
Summary Odor information is processed in the olfactory bulb (OB), which is organized into olfactory inputs, interneurons, projection neurons, and centrifugal inputs, and these various structures regulate olfactory information processing. Similar to other brain regions, the OB structures include many types of interneurons, including γ-aminobutyric acid (GABA)ergic interneurons. Many interneurons are granule cells that are found in the granule cell layer (GCL), which is a deep layer of the OB. Interestingly, these interneurons exhibit variations in GABA immunoreactivity, and previous studies have observed differing intensities among morphologically and chemically similar neuronal populations. However, the numbers and distribution patterns of cells that show variations in GABA immunoreactivity are unknown. Therefore, we observed and quantitatively analyzed this diversity in the GCL of the mouse OB using immunogold, high-voltage electron microscopy, combined with light microscopy. Consequently, our results clearly show variations in the GABA immunoreactivity among GCL interneurons, which suggested heterogeneity in the amount of GABA present in each interneuron and reflected the possibility that different amounts of neuroactive substances may be associated with different functions for the various GABAergic interneuron groups. Variations in GABA immunoreactivity could be a novel criterion for classifying interneuron subpopulations.
DOI 10.1016/j.neulet.2020.135386
PMID 32947006