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イワモト タカユキ
Takayuki Iwamoto
岩本 高行 所属 川崎医科大学 医学部 臨床医学 乳腺甲状腺外科学 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Young adult breast cancer patients have a poor prognosis independent of prognostic clinicopathological factors: a study from the Japanese Breast Cancer Registry. |
| 掲載誌名 | 正式名：Breast cancer research and treatment 略 称：Breast Cancer Res Treat ISSNコード：15737217/01676806 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 160(1),pp.163-172 |
| 著者・共著者 | Akemi Kataoka, Takayuki Iwamoto, Eriko Tokunaga, Ai Tomotaki, Hiraku Kumamaru, Hiroaki Miyata, Naoki Niikura, Masaaki Kawai, Keisei Anan, Naoki Hayashi, Shinobu Masuda, Koichiro Tsugawa, Kenjiro Aogi, Takanori Ishida, Hideji Masuoka, Kotaro Iijima, Takayuki Kinoshita, Seigo Nakamura, Yutaka Tokuda |
| 担当区分 | 2nd著者,責任著者 |
| 発行年月 | 2016/11 |
| 概要 | PURPOSE:The aim of this study was to investigate whether young age at onset of breast cancer is an independent prognostic factor in patients from the Japanese Breast Cancer Registry, after adjustment of known clinicopathological prognostic factors.METHODS:Of the 53,670 patients registered between 2004 and 2006 and surveyed after a 5-year follow-up prognosis, 25,898 breast cancer patients (48.3 %), who were obtained prognostic data, were examined. Clinicopathological factors were compared between young adult (YA; <35 years), middle-aged adult (MA; 35-50 years), and older adult (OA; >50 years) patients. Five-year disease-free survival (DFS) and overall survival (OS) rates were studied.RESULTS:YA patients were associated with an advanced TNM stage and aggressive characteristics (e.g. human epidermal growth factor receptor 2 (HER2)-positive or oestrogen receptor (ER)-negative breast cancers) compared to MA and OA patients (P < 0.001). The 5-year DFS and OS rates were 79.4 % and 90.8, 88.5 and 95.0 %, and 87.8 % and 91.6 % for YA, MA, and OA patients, respectively. From the multivariable regression analysis, young age at onset was confirmed as an independent prognostic factor for both DFS (hazard ratio 1.73, 95 % confidence interval 1.42-2.10; P < 0.001) and OS (hazard ratio 1.58, 95 % confidence interval 1.16-2.15; P = 0.004).CONCLUSIONS:Young age at onset is an independent negative prognostic factor in breast cancer. Further studies are required to develop new therapeutic strategies for YA breast cancer patients. |
| DOI | 10.1007/s10549-016-3984-8 |
| PMID | 27647460 |