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Takayuki Iwamoto
Department Kawasaki Medical School Kawasaki Medical School, Department of Breast and Thyroid Surgery, Position Assistant Professor |
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| Article types | 原著 |
| Language | English |
| Peer review | Peer reviewed |
| Title | The impact of donor age on the outcome of adult living donor liver transplantation. |
| Journal | Formal name：Transplantation Abbreviation：Transplantation ISSN code：00411337/00411337 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 85(9),pp.1240-5 |
| Author and coauthor | Takayuki Iwamoto, Takahito Yagi, Yuzo Umeda, Daisuke Sato, Hiroyoshi Matsukawa, Hiroaki Matsuda, Susumu Shinoura, Hiroshi Sadamori, Kenji Mizuno, Ryuichi Yoshida, Noriaki Tanaka |
| Authorship | Lead author |
| Publication date | 2008/05 |
| Summary | BACKGROUND:The negative effects of increased donor age on liver transplantation became evident in deceased donor liver transplantation. In living donor liver transplantation (LDLT), the details remain unclear.METHODS:Initially, 137 adult LDLT recipients from August 1996 to May 2005 were divided into two groups (donors <50 years of age: n=99, donors >or= 50 years of age: n=38) for the retrospective study. Then, 24 recipients who received LDLT from June 2005 to July 2006 were divided into two groups: group 1 (donors <50 years of age, n=14) and group 2 (donors >or= 50 years of age, n=10) and enrolled in the prospective study to analyze their clinical course and prognostic factors in the aged graft.RESULTS:In the retrospective study, the younger donor group had significantly better survival than that of the aged donor group (P=0.015, Log rank test). In the prospective study, the postoperative graft functions showed that the serum total bilirubin levels were significantly lower in group 1 (P<0.02, by ANOVA analysis). The phosphorylated-Signal Transducer and Activator of Transcription3 expression at 4 hr after reperfusion (RT2) in group 2 was significantly lower than that in group 1. At RT2, the expressions were up-regulated in group 1, but were down-regulated in group 2. The serum 8-hydroxydeoxyguanosine value became significantly higher in group 1 two weeks after LDLT.CONCLUSIONS:In the near term, Signal Transducer and Activator of Transcription3 gene induction during cold preservation may be of great use in improving the outcome of aged grafts in LDLT. |
| DOI | 10.1097/TP.0b013e31816c7e90 |
| PMID | 18475178 |