タイラ　ナルト   Naruto Taira   平　成人    所属   川崎医科大学  医学部 臨床医学　乳腺甲状腺外科学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Prospective cohort study of febrile neutropenia in breast cancer patients administered with neoadjuvant and adjuvant chemotherapies: CSPOR-BC FN study.
掲載誌名	正式名：Breast (Edinburgh, Scotland) 略　 称：Breast ISSNコード：15323080/09609776
掲載区分	国外
出版社	ELSEVIER
巻・号・頁	56,pp.70-77
著者・共著者	Ishikawa Takashi, Sakamaki Kentaro, Narui Kazutaka, Nishimura Hideki, Sangai Takafumi, Tamaki Kentaro, Hasegawa Yoshie, Watanabe Ken-Ichi, Suganuma Nobuyasu, Michishita Shintaro, Sugae Sadatoshi, Aihara Tomohiko, Tsugawa Koichiro, Kaise Hirose, Taira Naruto, Mukai Hirofumi,
発行年月	2021/04
概要	BACKGROUND:As Asians are more vulnerable to febrile neutropenia (FN) than Caucasians, evaluations of FN incidence and risk factors in Asians are important for the appropriate use of primary pegfilgrastim (PEG-G).PATIENTS AND METHODS:Japanese breast cancer patients receiving standard adjuvant chemotherapies were prospectively enrolled in multicenter institutions from August 2015 to July 2017. FN was evaluated from 2 treatment policies: true FN (T-FN): ≥37.5 °C, grade 4 neutropenia, mandatory hospital visit (visiting); surrogate FN (S-FN): ≥37.5 °C, oral antibiotic, no mandatory visit (non-visiting). PEG-G was used at the physicians' discretion. The primary endpoint was FN incidence during all cycles. Multivariate logistic regression analysis was performed to identify T-FN risk factors.RESULTS:Of 1005 enrolled patients, 980 women treated with FEC, E(A)C, and TC were analyzed. The FN incidence proportions in all patients were 22.5%, 27.5%, and 33.9% for FEC, E(A)C, and TC, respectively. Those of T-FN were 27.7%, 22.4%, and 36.6%; those of S-FN were 17.3%, 32.4%, and 31.5% with more frequent primary PEG-G usage. The relative dose intensity (RDI) of the 3 regimens was ≥0.85 in both groups. In the analysis of risk factors, TC (odds ratio = 2.67), age ≥ 65 years (2.24), and pretreatment absolute neutrophil count (ANC)/1000 μl (0.8) remained significant.CONCLUSIONS:FN incidences were above 20% in the 3 regimens, with TC showing the highest. RDI was maintained at a high level in both visiting and non-visiting groups. Patient-related risk factors were age and pretreatment ANC.
DOI	10.1016/j.breast.2021.01.005
PMID	33631458