杉山　斉
   Department   Kawasaki college of Health Professions  ,
   Position   Professor
Article types 原著
Language English
Peer review Peer reviewed
Title Seasonal variations in renal biopsy numbers and primary glomerular disease features based on the Japan renal biopsy registry.
Journal Formal name：Scientific reports
Abbreviation：Sci Rep
ISSN code：20452322/20452322
Domestic / ForeginForegin
Volume, Issue, Page 13(1),pp.5123
Author and coauthor Go Kanzaki, Nobuo Tsuboi, Takashi Yokoo, Noriko Uesugi, Kengo Furuichi, Akira Shimizu, Hitoshi Sugiyama, Hiroshi Sato, Hitoshi Yokoyama,
Publication date 2023/03
Summary We analyzed the seasonal variations in the number of renal biopsies and clinical characteristics of primary glomerular disease in Japan using the Japan Renal Biopsy Registry (J-RBR). We retrospectively collected clinical and pathological data of patients with primary glomerular disease who were registered in the J-RBR between 2007 and 2018. Immunoglobulin A nephropathy (IgAN), minimal change nephrotic syndrome (MCNS), membranous nephropathy (MN), and postinfectious acute glomerulonephritis (PIAGN) constituted the four major glomerular disorders included in this study (total, 13,989; IgAN, 9121; MCNS, 2298; MN, 2447; and PIAGN, 123). The number of patients with IgAN or MCNS was higher during summer. However, no overt seasonal variations were observed in patients with MN or PIAGN. Subgroup analyses suggested that in the patients with IgAN, more renal biopsies of severe cases were performed during winter, probably owing to age and blood pressure. Furthermore, more renal biopsies of severe cases were performed during spring and winter in patients with MCNS even after adjusting for the abovementioned host factors. This study suggests that seasonal factors influence the decision to perform renal biopsy as well as the pathogenesis of primary glomerular disease. Thus, our findings may provide important insights regarding the pathophysiology of primary glomerular disease.
DOI 10.1038/s41598-023-32182-7
PMID 36991090